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During AD, an uncoupling between the insulin receptor (IR) and the insulin receptor substrate 1 (IRS1) occurs as a consequence of the downregulation of IR expression and/or the inactivation of IRS proteins leading to the inability of insulin to promote its normal cellular downstream outcomes

doi: 10.1016/S1359-6446(03)02703-X

Ageing Res Rev 83:101775

Additionally, its administration has been linked to a decrease in lipid peroxidation levels [189] and an increase in both sperm count and motility [190]

325 Marnett and co-workers studied these mechanisms and the ensuing products by hematin-catalyzed degradation of oleic, linoleic and linolenic hydroperoxides

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