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As anticipated, chemical inhibition of SLC7A11 by erastin lowered intracellular GSH and GSH:GSSG (Figure 4A)

According to research conducted in 2008, the body only absorbs about 1.3% of a 1,000 mcg oral dose of B12

Some IC/BPS patients have bladder-centric phenotypes (e.g., Hunner lesions, small bladder capacity, pain improved with intravesical local anesthetics)

Women tend to experience more gastrointestinal side effects at each dose level in clinical trial data, though the difference is not large enough to warrant a different escalation schedule