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Subsequently, lipid peroxidation promoted the activation of IB kinase- (IKK)/NF-B, which further mediated chronic inflammation and impaired insulin signaling by inhibiting insulin-stimulated phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB) activities (53)
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This process can initiate oxidative stress through a feedback loop triggered by fatty acid peroxidation, leading to alterations in the lipid bilayer of cell membranes and the generation of free radicals (133)
In addition to Bcl-2, increased levels of members of the inhibitors of apoptosis (IAP) family including BIRC2 , BIRC3 , BIRC5/survivin , and XIAP are associated with cisplatin resistance and worse clinical outcome in patients of ovarian, esophageal, or head and neck cancer (Supplementary Table S1)
Borasio GD, Robberecht W, Leigh PN, et al
Finally, the third variant, psbA2 , is 5988% similar to psbA1 (discontinuously
