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Secondary effects from IGF-1 therapy were reported after administration of doses higher than 6080 g/kg/day

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[59] [60] Injection side effects include skin rash, itching, chills, fever, hot flushes, nausea and dizziness

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The peptides mechanism of action through beta-3 adrenergic receptors in adipose tissue is entirely separate from insulin signaling and glucose uptake pathways
