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10.1056/NEJMoa1901814 51 CorleisB.TzouanasC

155 Furthermore, GDH-derived NADPH is consumed to support the reductive carboxylation of -KG by IDH2, and the compensatory increase in the expression of GDH1 or GDH2 promote the growth of IDH-mutant glioma cells

As a result, ROS production increases, activating antioxidant responses [95, 226, 227]

They're dose-dependent and occur predictably

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"Nutritional Requirements of Pigs - Management and Nutrition"
