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10.1056/NEJMoa1901814 51 CorleisB.TzouanasC

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155 Furthermore, GDH-derived NADPH is consumed to support the reductive carboxylation of -KG by IDH2, and the compensatory increase in the expression of GDH1 or GDH2 promote the growth of IDH-mutant glioma cells

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As a result, ROS production increases, activating antioxidant responses [95, 226, 227]

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They're dose-dependent and occur predictably

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Monitoring blood pressure for those at high risk

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"Nutritional Requirements of Pigs - Management and Nutrition"

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