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Sanderson, C.M

International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine

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However, the compound's acidic nature (1% aqueous solution pH 2.5-3.0) imposes strict constraints when combined with alkaline excipients (calcium carbonate, potassium citrate), as neutralization generates localized heat and moisture, triggering premature capsule disintegration, powder discoloration, and content uniformity drift
