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The resulting H 2 O 2 is detoxified by APX which in turns oxidizes two Asc molecules, its specific electron donor

Metal chaperones such as CQ and PBT2, which maintain metal ion homeostasis, have been shown to restore cognition, elevate zinc levels in the hippocampus, and restore levels of key proteins involved in learning/memory and synaptic plasticity in ZnT3 knockout mice

Effects of iron overload on the immune system

Moore RY

Guerrero FD, Jones JT, Mullet JE

IL-17A promotes ferroptosis through multiple mechanisms: it transcriptionally represses myocyte enhancer factor 2C (MEF2C), a key positive regulator of GPX4 expression, thereby crippling the cellular antioxidant defense