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doi: 10.1007/s11695-015-1773-9
But the reason for this isn't clear.

Adverse events were reported in 10 patients, with six from the loading dose group and four from the no loading dose group
Signs and symptoms of a B12 deficiency are arms and legs that feel weak and sore, poor reflexes, unpleasant body odor, menstrual difficulties, diminished sensory perception, clumsiness, stammering and jerking limbs

Morning dosing covers work-related anxiety

How it was discovered: Scientists studying stomach ulcers noticed a particular protein sequence that protected the gut lining