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The time in range (TIR) index was used, derived from retrospective analysis of continuous glucose monitoring or FGMS

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Cell clusters have the potential to regenerate and repair a damaged disc, although the heavily cross-linked matrix in adult human discs 51 may frustrate even the largest clusters and lead instead to increased cell senescence 39,40 and apoptosis as represented here by the cell death marker Caspase-3 52,29

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Two components contribute to CAI