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128 They determined the brain-targeting efficiency after intranasal administration of a methotrexate solution (free MTX), methotrexate-loaded ISG (MTX-ISG), methotrexate-loaded niosome (MTX-N), and MTX-N-loaded ISG (MTX-N-ISG)

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Combined, these findings highlight the critical role of iron and ferritin in regulating the proliferation and invasion of CSCs in brain tumors, demonstrating that, depending on the availability of the LIP, CSCs modulate their cellular fate