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This defense system thus provides a critical layer of localized protection specifically within this susceptible organelle, offering new insights for understanding cellular resilience and identifying potential therapeutic targets in neurodegenerative disorders where mitochondrial dysfunction is a core pathological feature

Lancet 370 , 16441652 (2007)

Cell 172 , 373386.e310 (2018)

The resulting homogenates were subjected to centrifugation under specified conditions, and the supernatant was subsequently stored at -80C

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In vitro , they found that NNMT knockdown and NNMT inhibition by MNA both significantly increase the oxygen consumption in adipocytes