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The potential for scale-up is limited in thiol-induced inteins due to the higher costs of reagents required for tag cleavage
One negative aspect of utilizing maleimide chemistry for cysteine linkage has been its chemical instability in plasma, including a retro-Michael reaction which results in premature loss of the drug-linker from the ADC
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Composable microfluidic spinning platforms for facile production of biomimetic perfusable hydrogel microtubes
2023;10:e46e58
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