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At the same time, endothelial cell senescence also affects the delivery of nutrients and oxygen, leading to metabolic abnormalities and further accelerating organismal aging (Vronique et al., 2024)

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1 Introduction Degenerative orthopaedic diseases, such as osteoporosis (OP), osteoarthritis (OA), and lumbar disc herniation (LDH), gravely undermine patients quality of life

Various studies have reported that glutathione supplementation restores GSH levels and reduces oxidative muscle damage

Varga BR, Streicher JM, Majumdar S (2023) Strategies towards safer opioid analgesics-a review of old and upcoming targets