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Vitamin B12 is crucial for several physiological processes, including: Red blood cell formation deficiency leads to megaloblastic anaemia, characterised by large, immature red blood cells Neurological function B12 is required for myelin synthesis and nerve health DNA synthesis essential for cell division and growth Without adequate B12, patients may develop symptoms such as fatigue, pallor, shortness of breath, glossitis (sore tongue), paraesthesia (pins and needles), and in severe cases, neurological complications including peripheral neuropathy, ataxia, and cognitive impairment

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Studies confirmed that animals lacking these receptors showed no lipolytic response, validating this as the primary pathway

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Few studies are available for BRVO patients alone.126,127 Rabena et al.126 reported a significantly increased VA and reduced macular thickness after treatment with 1.25 mg bevacizumab in a retrospective study of 27 patients with BRVO

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