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Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice

However, the mechanism by which truncated Syn variants sequester cellular proteins and damaged organelles to drive LB nucleation remains poorly understood

Therefore, targeted therapeutics that block this oncogenic pathway, including BRAF and mitogen-activated protein kinase (MEK) inhibitors (BRAFi and MEKi, respectively), are widely used to treat metastatic melanoma 6

doi: 10.1016/j.jbc.2022.101612 172 McCauleyM

Notably, TFAM loss does not impair T cell development or activation (87)

Moreover, the iron-sulfur protein (2Fe-2S) NEET mediates the export of sulfur ions and iron between the cytosol and the mitochondria