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Its regulation involves a complex interplay among iron metabolism, the cystine/glutamate antiporter (system Xc-)/GSH/GPX4 antioxidant pathway, and lipid peroxidation processes [111]

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A pilot study suggested that doses above 50 mg/kg could be lethal, setting the highest screening dose for IP injections at 50 mg/kg (456)

[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Song L., Chen L., Zhang X., Li J., Le W