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Other GLP-1R, GIPR, and glucagon receptor (GCGR) poly-agonists are in development and have been tested in phase 1 and phase 2 clinical trials, including GLP-1R/GCGR agonists, GLP-1R/GLP-2R agonists, and triple GLP-1R/GIPR/GCGR agonists (abstracts presented at the American Diabetes Association Annual Meeting in June, 2022 and (7))

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free soluble), remain a complex and poorly understood field ( 6.2 Future directions: HLA-G as a next-generation checkpoint for precision medicine To unlock the full potential of HLA-G, the field must pivot from its current exploratory phase to one defined by rigorous standardization and mechanistic precision
