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Contributions of depressive mood and circulating inflammatory markers to coronary heart disease in healthy European men: The Prospective Epidemiological Study of Myocardial Infarction (PRIME) Circulation

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The selection of these five variables, as well as the cut-off values for bilirubin and albumin were empirical

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Initial crash (24-48 hours): Extreme exhaustion Often sleeping for extended periods Your body beginning to recover from stimulant effects Peak symptoms (2-3 days after last use): Most intense discomfort Fatigue and body aches Depression and irritability Strong cravings Sleep problems Difficulty concentrating Acute phase (up to 1-2 weeks): Symptoms gradually improve during this time, though you may still experience fatigue, mood changes, and cravings as your brain works to restore normal dopamine functioning