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Constitutive expression of cytochrome P450 1B1 endows testicular Leydig cells with susceptibility to 7,12-dimethylbenzanthracene-induced cell death

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This group had previously shown in the streptozotocin (STZ)-induced uncontrolled diabetic rat that intracerebroventricular administration of leptin returned glucose to normal, restored BAT glucose uptake, and normalized serum T 4 and BAT UCP1 mRNA levels (92)

The results are similar to previous findings that dietary supplementation with LC reduced malondialdehyde levels while increasing antioxidant enzymes such as CAT, SOD, and GSH (Li et al