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In general, EVs act as pro-inflammatory signals by activating immunological cells through the transfer of inflammatory mediators, promoting cytokine production, and ultimately recruiting immune cells

In the M-ARCOL model (Mucosal Artificial Colon, an advanced in vitro system using microbiota from healthy donors), daily exposure to PEMPs for 14 days increased pathobiont Desulfovibrionaceae (Fournier et al., 2023)

Promote cell proliferation and inhibit apoptosis The E-P-OS network activates pro-survival and proliferation pathways such as PI3 K/Akt/mTOR, leading to the overexpression of Cyclin D1, c-Myc, PCNA, and Ki67 in uterine fibroid cells

Zeman, M., Okuliarova, M

C., DeBuysere M

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