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According to a study on LPS-induced ARDS, Nrf2 inhibits oxidative stress and attenuates ferroptosis via controlling the amounts of ferroptosis-related proteins, such as SLC7A11 and GPX4

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26 In addition, the activity of the cytochrome P450 reductase (POR) also requires NADPH, which has a major role in the metabolism of drugs, xenobiotics, and steroid hormones