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Wells Fargo Securities: 2014

doi: 10.1016/j.biortech.2009.02.014 106

Lower dosage because of enhanced bioavailability
However, as with aerobic glycolysis inhibitors, metformin alone exhibited limitations in its effectiveness in in vitro trials

For instance, in vitro studies demonstrated that mitochondrial respiratory chain dysfunction, induced by exogenous inhibitors of Complex I (rotenone) and Complex II (3-nitropropionic acid), was alleviated by KBs [59]

Other potential side effects include cornea verticillata (similar to those seen with amiodarone use), conjunctival hemorrhage, blepharitis, reticular corneal edema and allergic conjunctivitis
