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[64] propose that commensals in the gut activate TLR-MyD88 signaling

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Nat Rev Drug Discov 23(8):583606

The treatment with a sub-efficacious dose of CB-839 resulted in a median survival time of 42 days

The proposed mechanism involves inhibiting serotonin reuptake in synapses, thereby prolonging elevated levels and enhancing its positive impact on mood regulation