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Early evidence of nuclear-specific PtdIns functions included the observation that IGF-1 treatment of cells in culture induced decreases of phosphatidylinositol 4-phosphate (PI4P

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Features that suggest melanoma include rapid growth, irregular borders, multiple colours within one lesion, bleeding or ulceration, and asymmetry

Friedrich, Jr

4 Chronic exposure to UVR can also cause slow-growing melanomas to develop on patches of sun-damaged skin in older people

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