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THF plays an important role in DNA synthesis, so reduced availability of THF results in ineffective production of cells with rapid turnover, in particular red blood cells, and also intestinal wall cells which are responsible for absorption

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11) Vitamin B12 is required to make red blood cells

Griffin, LD, MacGregor, GR, Muzny, DM, Harter, J, Cook, RG and McCabe, ERB (1989) Hexokinase 1 (HK1) cDNA probe synthesis by mixed oligonucleotide primed amplification of cDNA (MOPAC) using high complexity primer mixtures

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89,90 Activation of TLRs leads to the production of antiviral cytokines such as type I IFNs, IL-1, and IL-6, which directly impede viral replication