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Other sources of ROS include enzymatic activities such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which produces superoxide (O 2 )

The Nomenclature Committee on Cell Death (NCCD) classifies cell death into two broad categories based on functional and mechanistic criteria: accidental cell death (ACD), a passive process, and regulated cell death (RCD), an active, gene-controlled mechanism ( Ferroptosis, first identified and described by Dixon et al

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Once the patients condition has stabilized, a rehabilitation program should be planned for the patient as early as possible 135,137,138,139

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On the other hand, oxidative mtDNA is released into the cytoplasm due to the elevated MMP, triggering innate immune responses, such as NLRP3 activation, and subsequently leading to the upregulation of inflammatory factors like IL-1 [16]