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This level of quality control is absent in the gray market

The absence or overexpression of Piezo1 leads to abnormalities in the organism, such as hippocampal dysfunction (Xiong et al., 2022), cavernous cerebral malformation (Scimone et al., 2022), peritumoral brain edema (Qu et al., 2020a), and CNS demyelination (Velasco-Estevez et al., 2020)

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A solid CAPA plan should include a clear look at what caused the issue, a written plan for how youll correct it, and who will be responsible for each part of the work

Z tego wynikaj konkretne ograniczenia, ktre trzeba mie na uwadze: Dominuj modele przedkliniczne hodowle komrkowe i badania na zwierztach