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Corresponding changes were observed at the phylum level (Figure S2D), where volcano plot analysis revealed marked alterations between groups, including pronounced upregulation of Pseudomonadota and Bacteroidota in the hCiPSCs-treated group, whereas Actinomycetota, Deferribacterota, and Bacillota were significantly depleted

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[0211] Embodiment 204: The chimeric antigen receptor of embodiment 202, wherein said costimulatory signaling region comprises 4-1BB

Cytokine levels were acquired using a FACSCanto II flow cytometer (BD Biosciences) and analyses were performed using LEGENDplex data analysis software (BioLegend)