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However, genetic variations, impaired hepatic processing, altered enterohepatic recycling, and gut microbiota imbalances can lead to bilirubin supersaturation, increasing the risk of gallstone formation

The role of erastin in ferroptosis and its prospects in cancer therapy

Nat Commun 6(1):7506

Sharma and Dietz, 2006
doi: 10.1006/jsre.1997.5080