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In malignant peripheral nerve sheath tumors, these inactivations of PRC2 components significantly co-occurred with somatic alterations of CDKN2A (81% of all MPNST) and NF1 (72% of non-NF1-associated MPNST)

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48,149,150,151 These findings underscore the value of PI3K/AKT pathway signaling proteins as targets for the treatment of immune cell-mediated autoimmunity and malignancy

However, the fluorophores responsible for gut granule autofluorescence remain largely undefined

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[15] Low-grade sarcomas have a better prognosis than higher-grade sarcomas, and are usually treated surgically, although sometimes radiation therapy or chemotherapy are used