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9 It is important to note that for patients presenting solely with erythema migrans, the clinical diagnosis of Lyme disease may be considered even in the absence of any laboratory testing

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For cells that are cycling, the presence of TET-mediated oxidation marks on one strand of CpG dinucleotides can promote passive DNA demethylation by preventing the methylation of the CpG on the opposite strand by DNMT1 after DNA replication, ( de novo methylation by DNMT3s during development