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If untreated, NASH progresses to liver cirrhosis, scaring of the liver, and hepatocellular carcinoma

Orforglipron significantly reduced HbA1c to 2.1% in a phase II clinical trial assessing its use in T2DM, while dulaglutide achieved 1.1% and a placebo achieved 0.43% [106]

BPC 157 therapy counteracted both the MDA-value increase as well as the oxidative stress damages in all organs tested at the end of all decompression/reperfusion periods, which were investigated to provide additional proof for the concept (Table 4)

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Although this group focused their study on SFs role in cancer prevention, both oxidative stress and inflammation are also critical factors in cognitive health