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The following data were collected: publication year, country and continent, study setting (e.g., hospital, private practice, academic clinic), sample size, age range, mean age, study design, population characteristics, intervention details, outcomes, and effect measures (e.g., serum B12 levels)

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Keywords: hyperhomocysteinemia, folic acid, vitamin B12, chronic kidney disease, end-stage renal disease, cardiovascular disease Introduction Chronic Kidney Disease (CKD) represents an important economic burden for health systems around the world, with an estimated global prevalence of between 11 and 13%

Vitamin C is a strong anti-oxidant that can be used IV to support the immune system, as well as help in healing and recovery from infection and inflammation

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