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As aquaporin-4 is mainly localized in the astrocyte endfeet, these are the primarily affected cells in this disease

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Di Lorenzo G, Iavarone F, Maddaluno M, Plata-Gmez AB, Aureli S, Quezada Meza CP, et al

found that Ras Selective Lethal 3 can induce ferroptosis in primary melanocytes, as reflected by suppressed cell growth, mitochondrial dysfunction, increased ROS production and iron ion accumulation [76]

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