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1,2 In a 2005 Cochrane review, patients who received high dosages of oral vitamin B 12 (1 to 2 mg daily) for 90 to 120 days had an improvement in serum vitamin B 12 similar to patients who received intramuscular injections of vitamin B 12

Journal of the American Chemical Society, 131(42), 15078-15079

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Injections bypass that step, so more B12 becomes available to tissues

Regular exercise is also beneficial after a B12 shot, as it promotes circulation and enhances the absorption of vitamin B12

It is believed that the Werner syndrome (WS), which is characterized by severe metabolic dysfunction, dyslipidemia, early atherosclerosis, and insulin resistance diabetes, most closely resembles the aging process (23)