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Clearance is related to the total drug concentration in the plasma (free + protein-bound) and not the free concentration

Macrophages and monocytes are the most enriched immune cell types in the lung of COVID-19 patients [162]

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MITF positively regulates pigmentation-associated genes to promote differentiation-associated function and directly transactivates promoters of three primary melanogenesis enzymes, tyrosinase (TYR), tyrosine-related protein-1 (TYRP-1), and dopachrome tautomerase, also known as tyrosine-related protein-2, TYRP-2 (-2) 55
