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Symptoms of B12 Deficiency Symptoms of B12 deficiency include: Skin with a yellowish undertone Sore and reddened tongue, and mouth ulcers Tingling in your extremities Fatigue, lethargy and apathy Alterations in walking gait and movement Vision problems Depression and irritability Behavioral changes Dark thoughts Poor memory and decision making Dry and brittle skin, hair and nails Infertility Benefits of B12 Injections and Infusions For many, eating more meat and animal products to boost Vitamin B12 is not an option, but your body cannot get by without at least baseline levels