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GH binding to its receptor (GH-R) triggers receptor dimerization and activation of the Janus kinase 2 (JAK2), initiating several intracellular signaling cascades, including signal transducer and activator of transcription (STAT), phosphatidylinositol 3-kinase (PI3-K), and mitogen-activated protein kinase (MAPK) pathways [6]
doi: 10.1016/S0140-6736(00)02799-9
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