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Abstract CT032: a phase 1/2, open-label, multicenter, dose escalation and efficacy study of mRNA-2416 (LNP encapsulated OX40L mRNA) alone or with durvalumab for patients with advanced malignancies

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When oxidative stress occurs, Nrf2 dissociates from Keap1 and translocates to the nucleus, where it binds to antioxidant response elements (AREs) in the promoter regions of specific genes, initiating their transcription process (170)