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In high-glucose-treated HK-2 tubular cells, MitoQ upregulated Nrf2 translocation, inhibited Kelch-like ECH-associated protein 1 (Keap1), and blocked M1 macrophage polarization and Th17 cell infiltration through mitochondrial quality control mechanisms, establishing a link between mitochondrial redox balance and immune cell dysregulation in DKD (126, 127)

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[24] HLA genes [edit] The first gene locus associated with autoimmune thyroid disease was the major histocompatibility complex (MHC) region on chromosome 6p21

doi: 10.1097/01.AOG.0000437382.03963.88

This stability partially explains why both nasal and oral administration routes remain viable options for delivery

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