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This work was supported by the Zhuhai Science and Technology Innovation Bureau (No.2320004000290 and No.2420004000022)

Ld: low dose

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The crystal structure of the inactive and phosphorylated kinase domain of the IGF-1R has provided a molecular model of the IGF-1R catalytic activity (Favelyukis et al, 2001)

Sephadex (cross-linked by glyceryl bridges) and Sephacryl (allyldextran cross-linked by N-methylenebisacrylamide) are the two types of dextran gel used in separation