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It is possible that the observed actions occurred through a complex signaling mechanism that involves the PI3K (Phosphoinositide 3-kinases) and AMPK (AMP-activated protein kinase) pathways
& Jensen, P
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In that report, the incidence of pancreatic cancer was also 2.9 and 2.7 times greater with exenatide and sitagliptin, respectively, compared to other oral antidiabetic medications
