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Carcinogenic effects were not conclusively determined for DNO

Smoyer A, Schwarz P, Camenga D , Rickey L

This is driven by the likelihood of subchondral bone changes as a consequence of failed repair, particularly if the first attempt involved disruption of the tidemark for marrow recruitment

If iron, B12 or other nutrients are dangerously low, IV therapy can replenish levels much faster than oral supplementation (weeks instead of months)

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