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Coln-GonzlezALSantanaRASilva-IslasCAChnez-CrdenasMESantamaraAMaldonadoPD

After excluding the duplicated, irrelevant, and no full-text-available articles, we included 156 studies in this narrative review

doi: 10.1073/pnas.1500722112 204 HammondMEHayesDFWolffACManguPBTeminS

In addition, NRF2 is regulated by the cytoplasmic inhibitor Kelch-like ECH-associating protein 1 (KEAP1)

This process rushes vital oxygen and nutrients to areas of the body that typically have very poor blood flow, such as tendons, ligaments, and cartilage, forcing them to heal at an accelerated rate