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The metabolic basis of cancer cachexia

Like POLG mutations, other genetic abnormalities that impair mtDNA replication, including C10orf2 , DGUOK , MPV17 , PEO1 , and SUCLG1 , are part of the hepatocerebral mitochondrial DNA depletion syndromes, which are syndromes that include prominent liver failure (70, 75, 76)
This indirect pathway creates some important differences in how these supplements work

Cucinotta D, Passeri M, Ventura S, and et al

doi:10.1056/NEJMoa1915925 Rezkalla SH, Kloner RA

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