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The SPTLC3 gene is located on chromosome 20p12.1 and is composed of 14 exons that generate two alternatively spliced mRNAs, both of which encode the same 552 amino acid protein

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Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

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In this context, male subjects are more likely to suffer from increased risk of alcohol-related diseases such as liver diseases, CVD, and GI cancers
