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namely, these are precursor protein for amyloid, presenilin 1 and 2, and protein tau associated with microtubules that regulate tau and amyloid formation in the brain
doi:10.1097/PSY.0b013e31816aa0dd McDonald MD, Lane-Fall M, Miano TA, et al

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The vicious cycle between metabolic dysfunction and inflammation underlies pathological processes of many chronic diseases such as obesity, insulin resistance, diabetes and cardiovascular disease

FurinDB: a database of 20-residue furin cleavage site motifs, substrates and their associated drugs
The maximal permitted tumour volume was set at 2000 mm
