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Importantly, women appear to respond well at lower injectable doses, and the most common approach combines topical and injectable use simultaneously for maximum cosmetic effect

This ensures youre getting exactly what your skin needs, resulting in better, longer-lasting results

A Cochrane review supports the use of high-dose vitamin B 12 (1 mg and 2 mg daily) in elevating serum vitamin B 12 level and achieving haematological and neurological responses, even in patients with PA or with ileal resection.58 The recommendation for oral replacement is 1 mg daily for a month, and then 125 to 250 g daily as maintenance dose for patients with dietary insufficiency and food-cobalamin malabsorption, while for PA the maintenance dose is 1 mg daily.29 Vitamin B 12 does not have side-effects even when prescribed in large doses.59 However, hypokalaemia, resulting from uptake of circulating potassium by newly growing and dividing haematopoietic cells, can be severe or sometimes life-threatening

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10.1016/j.ejphar.2006.11.048 [DOI] [PubMed] [Google Scholar] Hosli E., Hosli L

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