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The IC 1020 doses were experimentally derived and chosen to observe synergy (see Supplementary Table 1 for concentrations)

Int Urogynecol J

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Delayed valproic acid toxicity: a retrospective case series

Further, evidence suggests that increased expression of GluN1 subunits leading to activity-dependent enhanced targeting of NMDA receptors to the synapse involves alternative splicing of the carboxyl-terminal (C2 cassette) of GluN1 subunits (Mu et al., 2003