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Concomitant use of other drugs that cause central nervous system (CNS) adverse reactions (e.g., alcohol, sedatives, hypnotics, opiates, and anxiolytics) or have anticholinergic properties (e.g., other belladonna alkaloids, sedating antihistamines, meclizine, tricyclic antidepressants, and muscle relaxants) may increase this effect [see Drug Interactions (7.1)]

In the context of tumor cells, the uptake of itaconate has been shown to result in the itaconylation of PD-L1 (programmed death ligand 1)

But the additional GIP receptor binding domain makes tirzepatide a fundamentally different pharmacological tool

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